Description

2'-Amino-2'-Deoxyadenosine is a modified nucleoside analog where the 2'-hydroxyl group of the ribose sugar is replaced by an amino group. This structural modification is of significant interest in medicinal chemistry and biochemistry for its role in studying enzyme mechanisms and as a potential building block for oligonucleotide synthesis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in drug discovery, biochemical research, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for nucleoside kinases and polymerases.
• Pharmaceutical Intermediates: Serves as a key synthetic precursor for the development of antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Acts as a modified building block (phosphoramidite) for the solid-phase synthesis of antisense oligonucleotides or aptamers with altered properties.
• Diagnostic Probe Development: Employed in the creation of labeled probes for studying nucleic acid interactions and detection assays.
• Metabolic Pathway Studies: Utilized to investigate the salvage pathways of nucleoside metabolism within cells.
• Academic & Institutional Research: A critical reagent for universities and research institutes exploring nucleic acid chemistry and biology.

Basic Information

Item	Details
Product Name	2'-Amino-2'-Deoxyadenosine
CAS No.	10414-81-0
Molecular Formula	C10H14N6O3
Molecular Weight	266.26 g/mol
Synonyms	9-[(2R,3S,5R)-3-Amino-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-amine; 2'-Deoxy-2'-aminoadenosine; 2'-Amino-2'-deoxyadenosine; 2'-NH2-dA; 2'-Amino-deoxyadenosine; Adenine 2'-amino-2'-deoxyriboside; 2'-Amino-2'-deoxy-A; 2'-Amino-2'-deoxyadenosine (2'-NH2-dA)
EINECS	Contact for details

Quality Control

Our 2'-Amino-2'-Deoxyadenosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.