Description

4-Methoxy-3-Nitrobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the 4-methoxy-3-nitrobenzoyl moiety, a key functional group for modifying molecular properties and bioactivity. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring specific aromatic substitution patterns.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the nitro and methoxy groups contribute to biological activity and selectivity.
• Peptide Mimetics & Conjugation: Employed in peptide chemistry for acylating amino groups or as a linker in the development of peptide-drug conjugates and biomolecules.
• Dye & Pigment Manufacturing: Serves as an intermediate for synthesizing complex azo dyes and organic pigments, contributing to color fastness and specific spectral properties.
• Liquid Crystal & Electronic Materials: A building block for synthesizing organic semiconductors and liquid crystal compounds due to its polarizable aromatic structure.
• Polymer Modification: Used to functionalize polymers through reactions with hydroxyl or amine groups on polymer chains, imparting new chemical properties.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed cross-coupling reactions for constructing complex biaryl systems.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	4-Methoxy-3-Nitrobenzoyl Chloride
CAS No.	10397-28-1
Molecular Formula	C8H6ClNO4
Molecular Weight	215.59 g/mol
Synonyms	3-Nitro-4-methoxybenzoyl chloride; 4-Methoxy-3-nitrobenzoic acid chloride; 3-Nitro-p-anisoyl chloride; 4-Methoxy-3-nitro-benzoic acid chloride; 4-Methoxy-3-nitrobenzoylchloride; p-Methoxy-m-nitrobenzoyl chloride; 4-Methoxy-3-nitro-benzoyl chloride; Benzoic acid, 4-methoxy-3-nitro-, chloride
EINECS	233-857-3

Quality Control

Our 4-Methoxy-3-Nitrobenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and compliance data for your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.