Description

2-Bromo-4-Cyanopyridine is a versatile and high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique bifunctional structure, featuring both a bromine substituent and a cyano group, makes it an indispensable intermediate for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as cross-coupling reactions and heterocyclic ring formation.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactivity for creating diverse heterocyclic scaffolds.
• Material Science & OLED Development: Serves as a building block for electron-transport materials and ligands in coordination chemistry for advanced electronic devices.
• Cross-Coupling Reactions: The bromine atom is an excellent site for Suzuki, Stille, and Buchwald-Hartwig amination reactions to introduce complex substituents.
• Ligand & Catalyst Preparation: Utilized for synthesizing specialized pyridine-based ligands used in homogeneous catalysis.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process R&D to explore new chemical spaces and optimize synthetic routes.

Basic Information

Product Name	2-Bromo-4-Cyanopyridine
CAS No.	10386-27-3
Molecular Formula	C6H3BrN2
Molecular Weight	183.01 g/mol
Synonyms	4-Cyano-2-bromopyridine; 2-Bromo-4-pyridinecarbonitrile; 2-Bromoisonicotinonitrile; 2-Bromo-4-cyanopyridine; 4-Cyano-2-bromopyridine; 2-Bromopyridine-4-carbonitrile; 10386-27-3; Bromo-4-cyanopyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Cyanopyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 99 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.