Description

Thymidylyl-(3'-5')Deoxyuridine is a dinucleoside monophosphate, a fundamental building block in nucleic acid chemistry. This compound is critical for research and development in oligonucleotide synthesis, serving as a model system and a key intermediate. It is primarily needed by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in antisense therapy development, diagnostic probe synthesis, and fundamental biochemical studies.

Application

• Oligonucleotide Synthesis: Acts as a crucial phosphodiester-linked dimer intermediate in the chemical and enzymatic synthesis of DNA and RNA strands.
• Biochemical Research: Used as a substrate or model compound for studying enzyme kinetics, particularly for nucleases, phosphorylases, and polymerases.
• Antisense & Therapeutic Development: Serves as a building block in the creation of antisense oligonucleotides and other nucleic acid-based therapeutic agents.
• Diagnostic Probe Manufacture: Employed in the production of labeled probes for hybridization assays, PCR, and other molecular diagnostic techniques.
• Reference Standard: Utilized as a high-purity analytical standard for quality control in molecular biology and pharmaceutical manufacturing.

Basic Information

Product Name	Thymidylyl-(3'-5')Deoxyuridine
CAS No.	10318-59-9
Molecular Formula	C20H26N4O12P
Molecular Weight	530.42 g/mol
Synonyms	dT-dU; Thymidylyl(3'→5')deoxyuridine; TpdU; Thymidine 3'-(deoxyuridine 5'-phosphate); 5'-dTMP-3'-dU; Deoxythymidylyl-(3'-5')-deoxyuridine; 2'-Deoxythymidylyl-(3'→5')-2'-deoxyuridine; d(TpU)
EINECS	Contact for details

Quality Control

Our Thymidylyl-(3'-5')Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. We provide Certificates of Analysis (COA) with detailed specifications to ensure the material meets the stringent requirements for research and pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.