Description

2'',3'',5''-Triacetyl-Azacytidine is a key protected derivative of the nucleoside analog Azacytidine, designed to enhance stability and facilitate specific synthetic pathways. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in oncology drug discovery, epigenetics research, and the development of nucleoside-based prodrugs.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of advanced Azacytidine analogs and related nucleoside therapeutics.
• Oncology Research: Used in the development and study of DNA methyltransferase (DNMT) inhibitors for epigenetic cancer therapies.
• Prodrug Synthesis: Serves as a protected precursor for creating prodrug forms with improved bioavailability and targeted delivery.
• Biochemical Research: Employed in studies investigating nucleoside metabolism, RNA incorporation, and cellular differentiation processes.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Details
Product Name	2'',3'',5''-Triacetyl-Azacytidine
CAS No.	10302-78-0
Molecular Formula	C14H18N4O8
Molecular Weight	370.32 g/mol
Synonyms	1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one; 5-Azacytidine 2',3',5'-Triacetate; 4-Amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; Ladakamycin triacetate; Azacitidine triacetate; NSC-102816 triacetate; 5-AZC triacetate
EINECS	Contact for details

Quality Control

Our 2'',3'',5''-Triacetyl-Azacytidine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.