Description

3'-o-Methylguanosine is a modified nucleoside derivative of guanosine, where a methyl group is attached to the 3' oxygen of the ribose sugar. This specific structural modification makes it a valuable biochemical tool and a key intermediate in nucleic acid research and pharmaceutical development. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleoside chemistry, antiviral drug discovery, and the study of RNA modifications and metabolism.

Application

• Biochemical Research: Used as a reference standard and precursor in studies of RNA methylation, cap structures, and nucleoside metabolism.
• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Enzymology Studies: Employed as a substrate or inhibitor for methyltransferases and other enzymes involved in nucleic acid processing.
• Diagnostic Development: Potential use in the development of assays and diagnostic kits targeting modified nucleosides as biomarkers.
• Life Science Reagents: Incorporated into specialized cell culture media or kits for metabolic labeling and tracing experiments.

Basic Information

Product Name	3'-o-Methylguanosine
CAS No.	10300-27-3
Molecular Formula	C11H15N5O5
Molecular Weight	297.27 g/mol
Synonyms	3'-O-Methylguanosine; Guanosine, 3'-O-methyl-; 3'-Methylguanosine; 9-[(3-O-Methyl-β-D-ribofuranosyl)]guanine; 3'-OMe-Guo; 3'-O-Me-G
EINECS	233-689-3

Quality Control

Our 3'-o-Methylguanosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.