Description

8-Azaadenosine is a purine nucleoside analog where a nitrogen atom replaces the carbon at the 8-position of the adenine ring. This structural modification is of significant interest in medicinal chemistry and biochemical research, as it can alter the compound's binding affinity and metabolic stability. It serves as a valuable building block and reference standard for researchers in pharmaceutical development and life sciences, particularly in the study of nucleoside metabolism and enzyme inhibition.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor for the development of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of adenosine-metabolizing enzymes like adenosine deaminase.
• Medicinal Chemistry: Acts as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Reference Standard: Employed as an analytical standard in quality control and method development for HPLC or LC-MS in pharmaceutical laboratories.
• Academic Research: Utilized in university and institutional labs for fundamental studies in chemical biology and nucleotide chemistry.

Basic Information

Product Name	8-Azaadenosine
CAS No.	10299-44-2
Molecular Formula	C10H12N6O4
Molecular Weight	280.24 g/mol
Synonyms	8-Azaadenosine; 8-Aza-9-β-D-ribofuranosyl-9H-purin-6-amine; 8-Azaadenosine, 9-β-D-Ribofuranosyl-8-azaadenine; 8-Aza-adenosine; 8-Azapurine riboside; 6-Amino-8-aza-9-β-D-ribofuranosyl-9H-purine; Tubercidin analog; 8-Nitrogenous adenosine derivative
EINECS	Contact for details

Quality Control

Our 8-Azaadenosine is produced under a rigorous quality management system. Each batch is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity determination by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.