Description

4-Isothiazolecarbonyl Chloride (7Ci,8Ci,9Ci) is a highly reactive acyl chloride derivative of the isothiazole heterocycle, serving as a critical building block in advanced organic synthesis. Its value lies in enabling the efficient introduction of the 4-isothiazolecarbonyl moiety, a key structural motif for imparting specific biological and chemical properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used to construct active ingredients for next-generation fungicides, herbicides, and insecticides, leveraging the bioactivity of the isothiazole ring.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials requiring specific heterocyclic functionalities.
• Chemical Biology Probes: Acts as a reagent for modifying proteins, peptides, and other biomolecules to study biological pathways and interactions.
• Dye and Pigment Manufacturing: Serves as an intermediate for creating complex heterocyclic dyes with enhanced color fastness and stability.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions to create complex, functionalized isothiazole derivatives.

Basic Information

Product Name	4-Isothiazolecarbonyl Chloride (7Ci,8Ci,9Ci)
CAS No.	10271-90-6
Molecular Formula	C4H2ClNOS
Molecular Weight	147.58 g/mol
Synonyms	Isothiazole-4-carbonyl chloride; 4-Carboxyisothiazole chloride; 1,2-Thiazole-4-carbonyl chloride; 4-Isothiazolecarboxylic acid chloride; 4-Isothiazolylcarbonyl chloride; 4-Isothiazole carbonyl chloride; 7CI,8CI,9CI-Isothiazolecarbonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Isothiazolecarbonyl Chloride is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP principles where applicable, ensuring the material meets the rigorous standards required for pharmaceutical and advanced chemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.