Description

3',4',5'-Trimethoxycinnamoyl Chloride is a versatile and highly reactive cinnamic acid derivative, serving as a crucial acylating agent and synthetic intermediate. Its value lies in its ability to efficiently introduce the trimethoxycinnamoyl moiety into target molecules, enabling the synthesis of compounds with enhanced biological activity and specific functionalities. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for creating novel drug candidates, bioactive natural product analogs, and advanced material precursors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential therapeutic agents, including kinase inhibitors, anti-inflammatory compounds, and neuroprotective drugs.
• Agrochemical Synthesis: Used in the production of novel pesticides and herbicides, leveraging the bioactivity of the trimethoxyphenyl group.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and advanced organic materials requiring specific cinnamate structures.
• Bioconjugation & Probe Development: Employed in biochemical research to label proteins, peptides, or other biomolecules for study and detection.
• Polymer Chemistry: Can be incorporated as a monomer or cross-linking agent to create polymers with unique optical or chemical properties.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	3',4',5'-Trimethoxycinnamoyl Chloride
CAS No.	10263-19-1
Molecular Formula	C12H13ClO4
Molecular Weight	256.68 g/mol
Synonyms	3,4,5-Trimethoxycinnamoyl Chloride; (E)-3-(3,4,5-Trimethoxyphenyl)acryloyl Chloride; Cinnamoyl Chloride, 3',4',5'-trimethoxy-; 3,4,5-Trimethoxy-trans-cinnamoyl Chloride; NSC 403697; 3-(3,4,5-Trimethoxyphenyl)-2-propenoyl Chloride
EINECS	Contact for details

Quality Control

Our 3',4',5'-Trimethoxycinnamoyl Chloride is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, alcohols, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.