Description

2'-Deoxy-2'-Fluoro-4-Thiouridine is a chemically modified nucleoside analog that serves as a critical building block in advanced biochemical research and pharmaceutical development. Its unique structure, featuring both fluorine and thiol modifications, makes it a valuable precursor for synthesizing oligonucleotides with enhanced stability and specific binding properties. This compound is primarily utilized by researchers and manufacturers in the fields of antisense oligonucleotide (ASO) therapeutics, diagnostic probe development, and RNA biochemistry.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key monomer for creating modified oligonucleotides used in therapeutic applications targeting gene expression.
• Diagnostic Probe Development: Used in the construction of fluorescent or radioactive probes for detecting specific RNA sequences in research and clinical diagnostics.
• RNA Structure-Function Studies: Incorporated into RNA strands to investigate RNA-protein interactions, folding, and stability due to its thiol and fluorine modifications.
• Pharmaceutical Intermediate: Serves as a crucial synthetic intermediate in the development of novel nucleoside-based antiviral or anticancer agents.
• Bioconjugation and Labeling: The 4-thio group provides a reactive handle for site-specific conjugation with labels, dyes, or other biomolecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic compounds with improved pharmacokinetic properties.

Basic Information

Item	Detail
Product Name	2'-Deoxy-2'-Fluoro-4-Thiouridine
CAS No.	10212-16-5
Molecular Formula	C9H11FN2O5S
Molecular Weight	278.26 g/mol
Synonyms	4-Thio-2'-deoxy-2'-fluorouridine; 2'-Deoxy-2'-fluoro-4-thiouridine; 2'-F-4-Thiouridine; 4-Thio-2'-F-uridine; 1-((2R,3R,4S,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-thioxo-1,2-dihydropyrimidin-2-one; 2'-Fluoro-2'-deoxy-4-thiouridine; 4-Thiouridine, 2'-deoxy-2'-fluoro-
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoro-4-Thiouridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support its use in pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. For long-term storage, consider keeping the product under inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.