Description

3',5'-Di-o-Acetyl-2'-Chloro-2'-Deoxyuridine is a key nucleoside analog derivative, specifically a halogenated and acetyl-protected deoxyuridine. This compound is a critical pharmaceutical intermediate used in the synthesis of more complex antiviral and anticancer agents. It is primarily required by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing novel therapeutic nucleosides.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating DNA/RNA synthesis inhibition and the mechanism of action of modified nucleosides.
• Antiviral Drug Development: Serves as a precursor in the research and production of potential drugs targeting viral polymerases.
• Anticancer Agent Synthesis: Employed in the development of chemotherapeutic agents that interfere with cancer cell DNA replication.
• Pro-drug Synthesis: The acetyl protecting groups make it a valuable intermediate for creating pro-drug forms of active nucleoside therapeutics.
• Reference Standard: Used as a high-purity analytical standard in quality control and method development for related pharmaceutical products.

Basic Information

Product Name	3',5'-Di-o-Acetyl-2'-Chloro-2'-Deoxyuridine
CAS No.	10190-39-3
Molecular Formula	C13H15ClN2O7
Molecular Weight	346.72 g/mol
Synonyms	2'-Chloro-2'-deoxy-3',5'-di-O-acetyluridine; 1-[(2R,4S,5R)-4-Chloro-5-(hydroxymethyl)-2-(acetyloxy)oxolan-2-yl]-5-pyrimidinone; 2'-Chloro-2'-deoxyuridine 3',5'-diacetate; 2'-Chloro-3',5'-di-O-acetyl-2'-deoxyuridine; 2'-Deoxy-2'-chlorouridine 3',5'-diacetate; NSC 38297; 3',5'-Diacetyl-2'-chloro-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Acetyl-2'-Chloro-2'-Deoxyuridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.