Description

2-Chloro-5-Phenylnicotinonitrile is a versatile and high-value pharmaceutical intermediate and fine chemical building block. Its molecular structure, featuring a chlorinated pyridine core and a phenyl nitrile group, makes it a critical precursor in modern synthetic organic chemistry. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its heterocyclic structure.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of molecular probes, enzyme inhibitors, and bioconjugation reagents.
• Academic & Contract Research: Essential reagent for methodological development in organic synthesis and catalysis studies within university and CRO laboratories.
• Fine Chemical Production: Intermediate for the manufacture of dyes, pigments, and other performance chemicals requiring specific aromatic nitrile functionalities.

Basic Information

Product Name	2-Chloro-5-Phenylnicotinonitrile
CAS No.	10177-10-3
Molecular Formula	C12H7ClN2
Molecular Weight	214.65 g/mol
Synonyms	2-Chloro-5-phenyl-3-cyanopyridine; 3-Cyano-2-chloro-5-phenylpyridine; 5-Phenyl-2-chloronicotinonitrile; 2-Chloro-5-phenylnicotinonitrile; 2-Chloro-5-phenyl-3-pyridinecarbonitrile; Nicotinonitrile, 2-chloro-5-phenyl-; 2-Chloro-5-phenyl-pyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Phenylnicotinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.