Description

7-Methylguanosine-5'-Monophosphate is a modified nucleoside monophosphate that serves as a key biochemical building block and research reagent. This compound is essential for studying RNA modification pathways, enzyme mechanisms, and cellular signaling processes. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers engaged in molecular biology, enzymology, and nucleotide analog synthesis.

Application

• Biochemical Research: Critical substrate for studying methyltransferases, RNA modification enzymes (like METTL1-WDR4 complex), and nucleotide metabolism.
• Pharmaceutical Development: Used in the research and synthesis of nucleotide analogs with potential therapeutic applications.
• Diagnostic Reagent Manufacturing: Serves as a component or standard in enzymatic assays and diagnostic kits targeting RNA modification status.
• Enzymology Studies: Employed to investigate enzyme kinetics, specificity, and inhibition for methyltransferase and kinase assays.
• Cell Signaling Research: Utilized in studies exploring the role of modified nucleotides in cellular processes and signal transduction.
• Reference Standard: Acts as a high-purity analytical standard for HPLC, LC-MS, or NMR in quality control and method development.

Basic Information

Product Name	7-Methylguanosine-5'-Monophosphate
CAS No.	10162-58-0
Molecular Formula	C11H16N5O8P
Molecular Weight	377.25 g/mol
Synonyms	7-Methyl-GMP; m7GMP; 7-Methylguanosine 5'-(dihydrogen phosphate); 7-Methyl-5'-GMP; Guanosine, 7-methyl-, 5'-(dihydrogen phosphate); 7-Methylguanosine monophosphate; N7-Methylguanosine-5'-monophosphate
EINECS	Contact for details

Quality Control

Our 7-Methylguanosine-5'-Monophosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. We provide Certificates of Analysis (COA) with detailed specifications to ensure traceability and compliance with research-grade standards. Custom purity grades and bulk quantities are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.