Description

2-Amino-5-Iodopyridine CAS NO 10127-97-2 is a halogenated aminopyridine derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both an amino group and an iodine atom on the pyridine ring, makes it a valuable precursor for constructing complex molecules via cross-coupling reactions. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to develop active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, ligands, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination, enabling rapid diversification of molecular scaffolds.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries for screening.
• Ligand Synthesis: Used to prepare nitrogen-containing ligands for catalysis and coordination chemistry.

Basic Information

Product Name	2-Amino-5-Iodopyridine
CAS No.	10127-97-2
Molecular Formula	C5H5IN2
Molecular Weight	220.01 g/mol
Synonyms	5-Iodo-2-aminopyridine; 5-Iodo-2-pyridinamine; 2-Pyridinamine, 5-iodo-; 2-Amino-5-iodopyridine; 5-Iodopyridin-2-amine; 2-Amino-5-iodo-pyridine; 5-Iodo-2-amino-pyridine
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.