Description

α-Pseudouridine is a naturally occurring modified nucleoside, a C-glycoside isomer of uridine, with the CAS registry number 10017-66-0. This compound is of significant value as a critical building block in the synthesis of therapeutic mRNA, where it enhances stability and reduces immunogenicity. It is essential for pharmaceutical R&D, biotechnology companies, and CDMOs focused on advanced nucleic acid therapeutics and vaccine development.

Application

• mRNA Vaccine & Therapeutic Synthesis: A key raw material for producing modified mRNA, improving translational efficiency and safety profiles.
• Pharmaceutical Intermediates: Serves as a high-purity intermediate in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies of RNA structure, function, and processing, including tRNA research and epitranscriptomics.
• Diagnostic Probe Development: Employed in the design and synthesis of labeled probes for detecting specific RNA sequences.
• Cell Culture & Media Supplements: Investigated as a component in specialized media to influence cellular processes and protein expression.

Basic Information

Product Name	α-Pseudouridine
CAS No.	10017-66-0
Molecular Formula	C9H12N2O6
Molecular Weight	244.20 g/mol
Synonyms	5-β-D-Ribofuranosyluracil; Pseudouridine; 5-Ribosyluracil; ψ-Uridine; 5-(β-D-Ribofuranosyl)uracil; NSC 406023; ψ
EINECS	233-000-3

Quality Control

Our α-Pseudouridine is manufactured under strict quality systems to meet the exacting standards of pharmaceutical and biotech applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant ICH guidelines and can support customer-specific validation requirements for drug substance registration.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.