Description

3β,11β,12β-Trihydroxy-5α-Androstane-17β-Carboxylic Acid Methyl Ester CAS NO 10005-91-1 is a high-purity steroidal intermediate of significant importance in advanced pharmaceutical synthesis. This compound is valued for its defined stereochemistry and functional groups, which make it a critical precursor in the development of specialized therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel corticosteroids and other bioactive steroid derivatives.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid APIs and other steroidal drugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic candidates.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in steroid analysis.
• Biochemical Research: Employed in studies investigating steroid hormone metabolism, receptor binding, and enzymatic pathways.
• Process Chemistry: Utilized in scaling up synthetic routes for pilot and commercial manufacturing of complex steroid molecules.

Basic Information

Product Name	3β,11β,12β-Trihydroxy-5α-Androstane-17β-Carboxylic Acid Methyl Ester
CAS No.	10005-91-1
Molecular Formula	C21H34O5
Molecular Weight	366.50 g/mol
Synonyms	Methyl 3β,11β,12β-trihydroxy-5α-androstane-17β-carboxylate; 3β,11β,12β-Trihydroxyandrostane-17β-carboxylic acid methyl ester; 17β-Carbomethoxy-3β,11β,12β-trihydroxy-5α-androstane; 5α-Androstane-17β-carboxylic acid, 3β,11β,12β-trihydroxy-, methyl ester; 10005-91-1; Methyl 3β,11β,12β-trihydroxy-5α-androstan-17β-oate
EINECS	Contact for details

Quality Control

Our 3β,11β,12β-Trihydroxy-5α-Androstane-17β-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.