Description

6-Fluoro-4-Hydroxycoumarin is a fluorinated derivative of the coumarin scaffold, a privileged structure in medicinal and synthetic chemistry. This compound matters as a versatile and high-value building block for the synthesis of more complex fluorinated molecules, offering enhanced metabolic stability and bioavailability. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by fine chemical manufacturers producing advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in oncology, anticoagulant, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the research and production of advanced fluorinated pesticides and herbicides, where the fluorine atom can improve activity and environmental persistence.
• Fluorescent Probe & Dye Precursor: Serves as a starting material for synthesizing specialized fluorophores and coumarin-based dyes used in biochemical assays and material science.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex heterocyclic compounds and exploring novel chemical reactions.
• Material Science Research: Investigated for use in the development of organic electronic materials and light-harvesting complexes due to its photophysical properties.

Basic Information

Product Name	6-Fluoro-4-Hydroxycoumarin
CAS No.	1994-13-4
Molecular Formula	C9H5FO3
Molecular Weight	180.13 g/mol
Synonyms	4-Hydroxy-6-fluorocoumarin; 6-Fluoro-4-hydroxy-2H-chromen-2-one; 6-Fluoro-4-hydroxy-2H-1-benzopyran-2-one; 6-Fluoroumbelliferone; 4-Hydroxy-6-fluoro-2H-chromen-2-one
EINECS	Contact for details

Quality Control

Our 6-Fluoro-4-Hydroxycoumarin is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	255 - 260 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.