Description

2-Fluoro-3-Bromo-5-Nitro Pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogen and nitro groups for bioactivity.
• Material Science Research: Serves as a building block for creating specialized ligands, functionalized polymers, and electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination.
• Nucleophilic Aromatic Substitution: The fluoro and nitro groups activate the pyridine ring for selective substitution, enabling diverse chemical modifications.

Basic Information

Product Name	2-Fluoro-3-Bromo-5-Nitro Pyridine
CAS No.	1868-58-2
Molecular Formula	C5H2BrFN2O2
Molecular Weight	220.98 g/mol
Synonyms	3-Bromo-2-fluoro-5-nitropyridine; 5-Nitro-3-bromo-2-fluoropyridine; 2-Fluoro-3-bromo-5-nitropyridine; Pyridine, 3-bromo-2-fluoro-5-nitro-; 1868-58-2; 3-Bromo-2-fluoro-5-nitro-pyridine; 2-Fluoro-3-bromo-5-nitro-pyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Bromo-5-Nitro Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly. Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.