Description

5-Amino-2-Fluoropyridine is a versatile fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an amino and a fluorine substituent, makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is essential for research and development in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients. Its high purity and consistent quality are paramount for ensuring reliable outcomes in sensitive chemical processes.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and stability.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Fluorine Chemistry Studies: A valuable substrate for investigating nucleophilic aromatic substitution and other reactions involving fluorinated heterocycles.
• Custom Synthesis and Contract Manufacturing: Supplied as a high-purity starting material for custom chemical synthesis and scale-up projects.

Basic Information

Product Name	5-Amino-2-Fluoropyridine
CAS No.	1827-27-6
Molecular Formula	C5H5FN2
Molecular Weight	112.11 g/mol
Synonyms	2-Fluoro-5-aminopyridine; 2-Fluoro-5-pyridinamine; 5-Amino-2-fluoropyridine; 2-Fluoropyridin-5-amine; 5-Pyridinamine, 2-fluoro-; 2-Fluoro-5-aminopyridine; 5-Amino-2-fluoro-pyridine
EINECS	217-376-8

Quality Control

Our 5-Amino-2-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure it meets the high-purity standards required for pharmaceutical and fine chemical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to guarantee supply reliability and batch-to-batch consistency for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The container should be kept tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.