Description

6α-Fluoro-16α-Methylpregn-4-Ene-3,20-Dione is a high-purity synthetic steroid intermediate of significant importance in pharmaceutical research and development. Its core value lies in its role as a key precursor for the synthesis of potent corticosteroid and progestogen analogs, enabling the development of advanced therapeutic agents. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and fine chemical industries, particularly those focused on steroid-based drug discovery and manufacturing.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of advanced corticosteroid drugs, including anti-inflammatory and immunosuppressive agents.
• Progestogen Development: Used in research and production of novel progestogen compounds for hormonal therapies.
• Process Chemistry: Serves as a key starting material in multi-step synthetic routes for complex steroid molecules in pilot and commercial-scale manufacturing.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Academic & Contract Research: Utilized in university and CRO settings for investigating new synthetic pathways and structure-activity relationships (SAR) of steroid derivatives.

Basic Information

Product Name	6α-Fluoro-16α-Methylpregn-4-Ene-3,20-Dione
CAS No.	1818-56-0
Molecular Formula	C22H31FO2
Molecular Weight	346.48 g/mol
Synonyms	6α-Fluoro-16α-methylpregn-4-ene-3,20-dione; 6α-Fluoro-16α-methylprogesterone; 6α-Fluoro-16α-methyl-4-pregnene-3,20-dione; 16α-Methyl-6α-fluoroprogesterone; Fluoro-methylprogesterone; NSC 47439; 6-Fluoro-16-methylprogesterone; 6α-Fluoro-16α-methyl-δ4-pregnene-3,20-dione
EINECS	Contact for details

Quality Control

Our 6α-Fluoro-16α-Methylpregn-4-Ene-3,20-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is accompanied by a detailed Certificate of Analysis (COA) available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.