Description

2-Methylestradiol is a synthetic derivative of the natural hormone estradiol, distinguished by the addition of a methyl group at the 2-position of the steroid nucleus. This structural modification can significantly alter its biological activity, receptor binding affinity, and metabolic profile compared to the parent compound, making it a valuable intermediate for advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in endocrinology, oncology, and the development of novel steroidal therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel steroidal drugs and hormone therapies.
• Biochemical Research: Used as a reference standard or probe in studies investigating estrogen receptor (ER) binding, selectivity, and downstream signaling pathways.
• Endocrinology Studies: Employed in preclinical research to explore the structure-activity relationships (SAR) of estrogen derivatives and their metabolic fate.
• Academic & Institutional Research: A critical reagent for universities and laboratories focusing on steroid chemistry, medicinal chemistry, and molecular biology.

Basic Information

Product Name	2-Methylestradiol
CAS No.	1818-12-8
Molecular Formula	C19H26O2
Molecular Weight	286.41 g/mol
Synonyms	2-Methylestra-1,3,5(10)-triene-3,17β-diol; 2-Methyl-17β-estradiol; 2-ME2; 2-Methoxyestradiol (isomer); Estra-1,3,5(10)-triene-3,17-diol, 2-methyl-; NSC 659853
EINECS	Contact for details

Quality Control

Our 2-Methylestradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets exacting standards for research use. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.