Description

2',3',5'-Tri-o-Benzoyluridine is a key benzoylated nucleoside derivative, primarily used as a critical protected intermediate in organic synthesis. Its value lies in providing selective protection for the ribose hydroxyl groups, enabling precise and efficient construction of complex oligonucleotides and modified nucleosides. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors engaged in nucleic acid chemistry, antiviral drug development, and oligonucleotide synthesis.

Application

• Oligonucleotide Synthesis: A vital protected intermediate for the solid-phase and solution-phase synthesis of RNA and modified oligonucleotides.
• Antiviral Prodrug Development: Serves as a precursor in the synthesis of nucleoside prodrugs, particularly for hepatitis C and other viral targets.
• Medicinal Chemistry Research: Used to create novel nucleoside analogs for screening and structure-activity relationship (SAR) studies.
• Bioconjugation & Labeling: Facilitates the site-specific introduction of labels, tags, or other functional groups onto nucleoside scaffolds.
• Process Chemistry & Scale-up: Employed in the kilogram-scale production of active pharmaceutical ingredients (APIs) for clinical trials and commercial manufacturing.

Basic Information

Product Name	2',3',5'-Tri-o-Benzoyluridine
CAS No.	1748-04-5
Molecular Formula	C31H24N2O9
Molecular Weight	568.53 g/mol
Synonyms	Uridine, 2',3',5'-tribenzoate; 2',3',5'-Tri-O-benzoyluridine; 1-[(2R,3R,4R,5R)-3,4-Bis(benzoyloxy)-5-(benzoyloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; Tribenzoyluridine; 2',3',5'-Tris-O-benzoyluridine; 2,3,5-Tri-O-benzoyl-β-D-ribofuranosyluracil; NSC 404058
EINECS	217-133-8

Quality Control

Our 2',3',5'-Tri-o-Benzoyluridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.