Description

4-Chloro-3-(Trifluoromethyl)Benzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of chloro and trifluoromethyl substituents, which introduce unique electronic and steric properties to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to synthesize active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the 4-chloro-3-(trifluoromethyl)phenyl moiety to modulate bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in manufacturing herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Liquid Crystal & OLED Material Production: Serves as a building block for advanced electronic materials and functional dyes.
• Polymer Chemistry: Acts as a monomer or modifying agent for introducing specific functional groups into polymer chains to alter material properties.
• Organic Synthesis Reagent: Employed in Friedel-Crafts acylation and other reactions to introduce the benzoyl group into complex molecular architectures.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and material science research to explore new compound libraries.

Basic Information

Item	Detail
Product Name	4-Chloro-3-(Trifluoromethyl)Benzoyl Chloride
CAS No.	1735-55-3
Molecular Formula	C8H3Cl2F3O
Molecular Weight	243.01 g/mol
Synonyms	4-Chloro-3-(trifluoromethyl)benzoyl chloride; 3-Trifluoromethyl-4-chlorobenzoyl chloride; 4-Chloro-alpha,alpha,α-trifluoro-m-toluoyl chloride; Benzoyl chloride, 4-chloro-3-(trifluoromethyl)-; 4-Chloro-3-trifluoromethylbenzoyl chloride; 4-Chloro-α,α,α-trifluoro-m-toluoyl chloride; m-Toluoyl chloride, 4-chloro-α,α,α-trifluoro-
EINECS	217-077-8

Quality Control

Our production of 4-Chloro-3-(Trifluoromethyl)Benzoyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and GC for residual solvents, to ensure consistency and compliance with customer specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and strong acid/organic solvent nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.