Description

20-α-Dihydrocortisol CAS NO 1719-79-5 is a synthetic corticosteroid derivative, specifically a hydrogenated form of cortisol. This compound is of significant value in pharmaceutical research and development as a key intermediate or reference standard for the synthesis and analysis of more complex steroid-based therapeutics. It is primarily needed by pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in the development of anti-inflammatory agents, hormone therapies, and other steroid-related products.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of advanced corticosteroid drugs and other bioactive steroid molecules.
• Reference Standard: Used in analytical chemistry for method development, validation, and quality control (QC) testing of steroid-based pharmaceuticals via HPLC, GC, or LC-MS.
• Biochemical Research: Serves as a tool compound in metabolic studies, receptor binding assays, and investigations into glucocorticoid and mineralocorticoid pathways.
• Process Development: Employed in scaling up and optimizing manufacturing processes for steroid APIs (Active Pharmaceutical Ingredients) under GMP conditions.
• Impurity Profiling: Acts as a known impurity or degradation product standard to monitor the stability and purity of cortisol and related corticosteroid preparations.

Basic Information

Item	Detail
Product Name	20-α-Dihydrocortisol
CAS No.	1719-79-5
Molecular Formula	C21H32O5
Molecular Weight	364.48 g/mol
Synonyms	20α-Dihydrocortisol; 11β,17α,21-Trihydroxy-5β-pregnane-3,20-dione; 5β-Pregnane-3,20-dione, 11β,17,21-trihydroxy-, (11β)-; 20α-Dihydrohydrocortisone; 20α-Hydrocortisol; 20α-Dihydrocortisone; 20α-Hydrocortisone; 20α-DHC
EINECS	Contact for details

Quality Control

Our 20-α-Dihydrocortisol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and reference standards. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), specific identification tests, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider storage under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Optical Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.