Description

1H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonitrile, 4-Amino-1-β-D-Ribofuranosyl- is a high-purity nucleoside analog building block of significant importance in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel therapeutic agents, particularly in the fields of oncology and virology. It is essential for research institutions, CROs, and pharmaceutical companies engaged in the development of targeted small molecule drugs and nucleotide-based therapies.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing nucleoside-based antiviral and anticancer drug candidates.
• Antiviral Drug Research: Used in the development of novel compounds targeting viral polymerases and replication mechanisms.
• Oncology Research: Serves as a precursor for creating targeted kinase inhibitors and other small molecule oncology therapeutics.
• Biochemical Research: Utilized in enzymatic studies and as a substrate or inhibitor in biochemical assays.
• Nucleotide Chemistry: Fundamental material for modifying nucleoside structures to explore new structure-activity relationships (SAR).
• Process Development: Employed in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs) under GMP conditions.

Basic Information

Product Name	1H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonitrile, 4-Amino-1-β-D-Ribofuranosyl-
CAS No.	1704-25-2
Molecular Formula	C12H13N5O4
Molecular Weight	291.26 g/mol
Synonyms	4-Amino-1-β-D-ribofuranosyl-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; 4-Amino-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; 4-Amino-1-(β-D-ribofuranosyl)-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; 4-Amino-1-β-D-ribofuranosyl-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 4-amino-1-β-D-ribofuranosyl-; 4-Amino-1-(β-D-ribofuranosyl)-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; Nucleoside analog intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonitrile, 4-Amino-1-β-D-Ribofuranosyl- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with research-grade and GMP-grade requirements to support various stages of drug development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.