Description

4-Bromoestradiol is a halogenated derivative of the endogenous estrogen hormone, estradiol, where a bromine atom is introduced at the 4-position of the aromatic A-ring. This structural modification is of significant interest in pharmaceutical research and development, particularly for creating molecular probes and potential therapeutic agents. It serves as a crucial synthetic intermediate and research chemical for scientists in the fields of endocrinology, oncology, and medicinal chemistry, enabling the study of estrogen receptor interactions and the development of novel targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel steroidal drugs and targeted cancer therapies.
• Biochemical Research: Used as a molecular probe to study estrogen receptor (ER) binding affinity, subtype selectivity (ERα vs. ERβ), and signal transduction pathways.
• Medicinal Chemistry: Serves as a precursor for the development of radio-labeled or fluorescent-tagged compounds for diagnostic imaging and biological tracing.
• Endocrinology Studies: Employed in vitro and in vivo research to investigate the effects of halogenated estrogens on hormonal regulation and metabolic processes.
• Reference Standard: Used as an analytical standard in high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for quality control and method validation in laboratories.

Basic Information

Product Name	4-Bromoestradiol
CAS No.	1630-83-7
Molecular Formula	C18H23BrO2
Molecular Weight	351.28 g/mol
Synonyms	4-Bromoestra-1,3,5(10)-triene-3,17β-diol; 4-Bromo-17β-estradiol; 4-Br-E2; Estra-1,3,5(10)-triene-3,17-diol, 4-bromo-, (17β)-; 4-Bromo-1,3,5(10)-estratriene-3,17β-diol; 4-Bromo-Estradiol
EINECS	Contact for details

Quality Control

Our 4-Bromoestradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.