Description

2-Fluoro-Atp CAS NO 1492-62-2 is a chemically modified adenosine triphosphate (ATP) analog where a fluorine atom is substituted at the 2' position of the ribose sugar. This structural modification is critical for its primary function as a potent and selective inhibitor of ATP-dependent enzymes, particularly kinases, making it an invaluable tool for probing cellular energy metabolism and signaling pathways. This high-purity biochemical is essential for researchers and developers in pharmaceutical discovery, enzymology, and molecular biology, where precise control over ATP-mediated processes is required.

Application

• Kinase Research & Drug Discovery: Serves as a substrate analog and competitive inhibitor in high-throughput screening assays to identify and characterize novel kinase inhibitors.
• Enzymology Studies: Used to investigate the mechanism, kinetics, and specificity of ATP-utilizing enzymes, including polymerases, ATPases, and phosphotransferases.
• Metabolic Pathway Analysis: A key tool for studying cellular energy metabolism, glycolysis, and oxidative phosphorylation by selectively blocking specific ATP-dependent steps.
• Structural Biology: Employed in X-ray crystallography and NMR studies to determine the three-dimensional structures of enzyme-inhibitor complexes.
• Diagnostic Assay Development: Utilized as a critical component in the development of sensitive diagnostic kits for monitoring kinase activity in clinical samples.
• Biochemical Probe Synthesis: Acts as a building block for synthesizing more complex, labeled probes for advanced cellular imaging and tracking studies.

Basic Information

Product Name	2-Fluoro-Atp
CAS No.	1492-62-2
Molecular Formula	C10H16FN5O12P3
Molecular Weight	527.18 g/mol
Synonyms	2'-Fluoro-ATP; 2'-Deoxy-2'-fluoro-ATP; 2'-F-ATP; Adenosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2'-fluoro-; 2'-Fluoroadenosine-5'-triphosphate; 2-F-ATP; 2-Fluoro adenosine triphosphate; 2'-Fluoro-5'-ATP
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-Atp is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of purity and biochemical activity. Our quality assurance protocol includes comprehensive characterization by HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and specific activity is provided with each shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Biological Activity	Confirmed by enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.