Description

5'-Adenylic Acid, 2-Fluoro- is a chemically modified nucleotide analog where a fluorine atom is substituted at the 2' position of the ribose sugar. This specific fluorination imparts unique biochemical properties, making it a valuable building block for research and development in advanced life sciences. It is primarily utilized by pharmaceutical researchers, diagnostic developers, and academic institutions working on nucleic acid chemistry and molecular biology. The compound is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for critical applications.

Application

• Pharmaceutical Research: Serves as a key intermediate in the synthesis of novel nucleoside-based therapeutics, including potential antiviral and anticancer agents.
• Probe and Primer Synthesis: Used in the manufacture of modified oligonucleotides for diagnostic assays, FISH probes, and PCR primers to enhance stability and specificity.
• Biochemical Studies: Employed as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of polymerases, nucleotidyltransferases, and other nucleic acid-metabolizing enzymes.
• Antisense and RNAi Technology: Incorporated into antisense oligonucleotides or siRNA strands to improve nuclease resistance and pharmacokinetic profiles.
• Structural Biology: Aids in X-ray crystallography and NMR studies to understand nucleic acid structure and protein-nucleic acid interactions.
• Standards and References: Functions as a high-purity analytical standard for quality control in nucleotide and oligonucleotide production.

Basic Information

Product Name	5'-Adenylic Acid, 2-Fluoro-
CAS No.	1492-60-0
Molecular Formula	C10H13FN5O6P
Molecular Weight	349.21 g/mol
Synonyms	2'-Fluoroadenosine 5'-monophosphate; 2'-F-AMP; 2'-Fluoro-5'-AMP; 9-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl] dihydrogen phosphate; Adenosine-2'-monophosphate, 2'-fluoro-; 2'-Fluoroadenylic acid; 2'-F-Ado-5'-MP
EINECS	Contact for details

Quality Control

Every batch of 5'-Adenylic Acid, 2-Fluoro- is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.