Description

5-α-Dihydrocortisone CAS NO 1482-51-5 is a synthetic corticosteroid derivative, specifically a reduced form of cortisone. This compound is of significant interest in pharmaceutical research and development due to its role as a key intermediate or reference standard in the synthesis and analysis of more complex steroid-based therapeutics. It is primarily required by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in the development of anti-inflammatory agents, metabolic regulators, and other steroid hormone-related products.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of more potent corticosteroid drugs and their analogs.
• Reference Standard: Used in analytical chemistry for method development, validation, and quality control (QC) testing of steroid-based pharmaceutical products via HPLC, GC-MS, or other chromatographic techniques.
• Biochemical Research: Employed in metabolic pathway studies to investigate the activity and regulation of steroid hormones and their derivatives.
• Preclinical Development: Utilized in the early-stage research and formulation of new therapeutic entities targeting inflammation, immune response, and endocrine functions.

Basic Information

Product Name	5-α-Dihydrocortisone
CAS No.	1482-51-5
Molecular Formula	C21H30O5
Molecular Weight	362.46 g/mol
Synonyms	5α-Dihydrocortisone; 17,21-Dihydroxypregn-4-ene-3,11,20-trione; 5α-Pregn-4-ene-3,11,20-trione-17,21-diol; 11-Dehydrocorticosterone; 5α-Dihydro-11-dehydrocorticosterone; Reichstein's Substance L; 5α-DHC
EINECS	216-011-7

Quality Control

Our 5-α-Dihydrocortisone is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and identification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.