Description

6Alpha-Hydroxyestrone is a key hydroxylated metabolite of the primary estrogen, estrone, playing a significant role in endogenous hormone metabolism and research. This compound is essential for scientists and manufacturers requiring high-purity reference standards and intermediates for advanced biochemical studies. It is primarily utilized in pharmaceutical R&D, clinical diagnostics, and as a critical building block in the synthesis of more complex steroid derivatives for therapeutic and analytical applications.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and qualification of estrogen metabolites in drug development and bioanalytical method validation.
• Biochemical Research: Used in metabolic pathway studies to understand the hydroxylation and detoxification pathways of endogenous estrogens.
• Diagnostic Kit Development: Acts as a critical antigen or calibrator in the development of immunoassays and LC-MS/MS kits for clinical hormone testing.
• Organic Synthesis Intermediate: Provides a functionalized steroid backbone for the synthesis of novel steroid-based compounds for therapeutic evaluation.
• Academic Research: Employed in university and institutional labs for endocrinology, toxicology, and cancer research related to estrogen metabolism.

Basic Information

Product Name	6Alpha-Hydroxyestrone
CAS No.	1476-78-4
Molecular Formula	C18H22O3
Molecular Weight	286.36 g/mol
Synonyms	6α-Hydroxyestrone; 6α-Hydroxy-1,3,5(10)-estratrien-3-ol-17-one; 3-Hydroxy-1,3,5(10)-estratrien-6α-ol-17-one; 6α-Hydroxyestra-1,3,5(10)-triene-3,17-dione; Estrone, 6α-hydroxy-; 6α-OHE1; 6α-Hydroxy-Oestrone
EINECS	Contact for details

Quality Control

Our 6Alpha-Hydroxyestrone is produced and tested under a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced chromatographic methods like HPLC. We support research and production needs with materials suitable for use as analytical references.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.