Description

6-Ketoestrone is a significant ketone derivative of the endogenous estrogen, estrone. This compound serves as a crucial intermediate and reference standard in the research and development of steroidal pharmaceuticals and biochemical studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in endocrinology, metabolic pathway analysis, and the synthesis of novel therapeutic agents. The consistent high purity of our product ensures reliable and reproducible results in sensitive analytical and synthetic applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of more complex steroidal drugs and hormone analogs.
• Biochemical Research: Used as a standard or reagent in studies investigating estrogen metabolism, enzyme activity (e.g., hydroxysteroid dehydrogenases), and metabolic pathways.
• Reference Standard: Serves as a high-purity calibrant in analytical methods such as HPLC, LC-MS, and GC-MS for the quantification of estrogens and their metabolites in various matrices.
• Endocrinology Studies: Employed in vitro and in vivo research to understand the biological activity and effects of estrogen derivatives.
• Academic & Industrial R&D: Fundamental material for discovery chemistry and the development of new diagnostic tools or therapeutic candidates targeting hormone-related conditions.

Basic Information

Product Name	6-Ketoestrone
CAS No.	1476-34-2
Molecular Formula	C18H22O3
Molecular Weight	286.36 g/mol
Synonyms	6-Oxoestrone; Estrone, 6-oxo-; 3-Hydroxy-1,3,5(10)-estratrien-6,17-dione; 6-Keto-Oestrone; 6-Oxo-Estrone; 6,17-Diketoestratriene-3-ol; 6-Oxoestra-1,3,5(10)-triene-3,17-diol
EINECS	Contact for details

Quality Control

Our 6-Ketoestrone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from techniques such as HPLC, NMR, and IR spectroscopy. Our quality commitment aligns with the standards expected for research and pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.