Description

5-Methyluridine is a modified nucleoside where a methyl group is substituted at the 5-position of the uracil base. This structural modification is critical for research into RNA biochemistry, epigenetics, and the development of novel therapeutic agents. It serves as a key building block and reference standard for scientists in pharmaceutical R&D, biotechnology, and academic institutions focused on nucleic acid chemistry and molecular biology.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel nucleoside analogs and antiviral/anticancer drug candidates.
• Biochemical Research: Acts as a crucial substrate or reference standard in studies of RNA modification, methylation pathways, and enzyme kinetics.
• Diagnostic Reagent Development: Employed in the creation of probes and assays for detecting specific RNA sequences or modifications.
• Antisense Oligonucleotide Synthesis: Serves as a modified monomer to enhance the stability and binding affinity of therapeutic oligonucleotides.
• Academic & Industrial R&D: Fundamental material for exploring the structure, function, and therapeutic potential of modified RNAs.

Basic Information

Product Name	5-Methyluridine
CAS No.	1463-10-1
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	5-Methyluridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methylpyrimidine-2,4-dione; 5-Methyl-1-β-D-ribofuranosyluracil; m5U; Ribothymidine; Thymine Riboside; 2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-β-D-ribofuranosyl-
EINECS	215-966-3

Quality Control

Our 5-Methyluridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.