Description

Cholic Acid Methyl Ester is a key methylated derivative of the primary bile acid, cholic acid. This high-purity intermediate is critical for pharmaceutical research and synthesis, offering a defined chemical structure for precise modification. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of more complex bile acid derivatives and steroid-based drugs.
• Biochemical Research: Used as a standard or reagent in studies of bile acid metabolism, liver function, and membrane biology.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC and LC-MS assays.
• Prodrug Development: Employed in the design and synthesis of prodrugs to enhance drug solubility and bioavailability.
• Chemical Synthesis: Acts as a starting material or protected intermediate in organic synthesis for introducing the cholic acid scaffold.
• Surfactant & Micelle Studies: Investigated for its amphiphilic properties in the formation of micelles and vesicles for drug delivery systems.

Basic Information

Product Name	Cholic Acid Methyl Ester
CAS No.	1448-36-8
Molecular Formula	C25H42O5
Molecular Weight	422.60 g/mol
Synonyms	Methyl Cholate; Cholic Acid Methyl Ester; 3α,7α,12α-Trihydroxy-5β-cholan-24-oic Acid Methyl Ester; Methyl 3α,7α,12α-trihydroxy-5β-cholan-24-oate; NSC 67071; Methyl 3,7,12-trihydroxycholanate
EINECS	215-902-6

Quality Control

Our Cholic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade specifications suitable for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	156 - 161 °C
Specific Rotation	+22° to +26° (c=1 in Ethanol)
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.