Description

Pseudouridine is a naturally occurring modified nucleoside, a C-glycoside isomer of uridine, with the CAS registry number 1445-07-4. This compound is a critical building block in the rapidly expanding field of mRNA therapeutics and vaccines, where it enhances stability and reduces immunogenicity. It is essential for research and production in the pharmaceutical, biotechnology, and life science sectors, particularly for companies developing advanced nucleic acid-based therapies and diagnostic tools.

Application

• mRNA Vaccine & Therapeutic Production: A key raw material for synthesizing modified mRNA to improve translational efficiency and stability.
• Biochemical Research: Used in studies of RNA structure, function, and modification mechanisms (epitranscriptomics).
• Pharmaceutical Intermediates: Serves as a high-purity intermediate for novel antiviral and anticancer drug candidates.
• Diagnostic Probe Development: Incorporated into nucleic acid probes for enhanced detection specificity in diagnostic assays.
• Cell Culture & Media Supplements: Utilized in specialized cell culture media for metabolic and genetic research applications.

Basic Information

Product Name	Pseudouridine
CAS No.	1445-07-4
Molecular Formula	C9H12N2O6
Molecular Weight	244.20 g/mol
Synonyms	5-Ribosyluracil; 5-(β-D-Ribofuranosyl)uracil; ψ-Uridine; 5-β-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione; β-Pseudouridine; NSC 406042; Pseudouridin; ψ
EINECS	215-889-2

Quality Control

Our Pseudouridine is manufactured under strict quality management systems. We offer grades suitable for research and GMP applications, with comprehensive testing to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each batch, confirming compliance with specifications for assay, related substances, residual solvents, and microbiological quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm
Bacterial Endotoxins	<1.0 EU/mg (for injectable grade)
Microbial Enumeration	Meets Ph. Eur. criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.