Description

12α-Hydroxy-5β-Cholan-24-Oic Acid Methyl Ester is a key methylated derivative of a primary bile acid, serving as a critical intermediate in the synthesis of complex steroid molecules and pharmaceutical agents. Its value lies in providing a protected carboxylic acid group, which is essential for precise chemical modifications in advanced organic synthesis. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic compounds, particularly in the fields of endocrinology and metabolic disease research.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel steroid-based drugs and bioactive molecules.
• Biochemical Research: Used as a reference standard or precursor in metabolic pathway studies and enzyme activity assays.
• Organic Synthesis: Serves as a protected intermediate for the selective functionalization of the steroidal core in complex multi-step syntheses.
• Analytical Chemistry: Employed as a high-purity standard for method development and calibration in chromatographic analysis (HPLC, GC).
• Academic Research: Utilized in universities and research institutes for studying bile acid chemistry, receptor interactions, and structure-activity relationships.

Basic Information

Product Name	12α-Hydroxy-5β-Cholan-24-Oic Acid Methyl Ester
CAS No.	1249-70-3
Molecular Formula	C25H42O4
Molecular Weight	406.60 g/mol
Synonyms	Methyl 12α-Hydroxy-5β-cholan-24-oate; Methyl 3α,7α,12α-Trihydroxy-5β-cholan-24-oate (common mis-assignment); 12α-Hydroxycholic Acid Methyl Ester; Methyl 12α-Hydroxycholate; 5β-Cholan-24-oic Acid, 12α-Hydroxy-, Methyl Ester; Lithocholic Acid Derivative; Bile Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our 12α-Hydroxy-5β-Cholan-24-Oic Acid Methyl Ester is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by chromatographic techniques (HPLC). A Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.