Description

1,3,5(10)-Estratrien-2,3,16Alpha,17Beta-Tetrol 2-Methyl Ether is a high-purity, synthetic steroid derivative, also known as 2-Methoxyestriol. This compound is a key advanced intermediate in the synthesis of complex steroid-based pharmaceuticals and research chemicals. It is essential for manufacturers and R&D laboratories requiring a reliable, high-quality building block for developing therapeutic agents and conducting biochemical studies. Its controlled purity and structural specificity make it a critical component for projects in endocrinology and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of specialized steroidal drugs and hormone analogs.
• Biochemical Research: Used as a reference standard or tool compound in studies of estrogen receptor activity and metabolic pathways.
• Academic & Contract Research: Serves as a starting material for novel compound libraries in medicinal chemistry programs at universities and CROs.
• Process Development: Employed in scaling up and optimizing synthetic routes for the production of steroidal active pharmaceutical ingredients (APIs).
• Analytical Standard: Utilized in quality control laboratories for method development and validation, including HPLC and mass spectrometry.

Basic Information

Product Name	1,3,5(10)-Estratrien-2,3,16Alpha,17Beta-Tetrol 2-Methyl Ether
CAS No.	1236-72-2
Molecular Formula	C19H26O5
Molecular Weight	334.41 g/mol
Synonyms	2-Methoxyestriol; Estriol 2-Methyl Ether; 2-Methoxy-1,3,5(10)-estratriene-3,16α,17β-triol; 16α,17β-Dihydroxy-2-methoxyestra-1,3,5(10)-trien-3-ol; NSC 9894; 2-MeO-E3
EINECS	214-974-7

Quality Control

Our production of 1,3,5(10)-Estratrien-2,3,16Alpha,17Beta-Tetrol 2-Methyl Ether adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the exacting standards required for pharmaceutical intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.