Description

2-Hydroxyestriol is a hydroxylated metabolite of the endogenous estrogen, estriol. This compound is of significant interest in biochemical and pharmaceutical research for its role in estrogen metabolism and potential biological activity. It serves as a critical reference standard and intermediate for researchers and manufacturers in the life sciences sector. Key applications include use in analytical method development, metabolic studies, and the synthesis of more complex steroid derivatives.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (HPLC, GC-MS) of estrogens in drug substances and finished products.
• Biochemical Research: Employed in studies investigating estrogen metabolism pathways, receptor binding affinity, and hormonal activity.
• Diagnostic Reagent Intermediate: Serves as a key starting material or intermediate in the synthesis of reagents for clinical diagnostic kits.
• Metabolite Profiling: Essential for identifying and quantifying estrogen metabolites in biological samples for toxicology and pharmacokinetic studies.
• Academic & Institutional Research: Used in universities and research institutes for fundamental endocrinology and steroid chemistry projects.
• Process Development: Acts as a model compound or intermediate in the development and scale-up of steroid synthesis processes.

Basic Information

Product Name	2-Hydroxyestriol
CAS No.	1232-80-0
Molecular Formula	C18H24O4
Molecular Weight	304.38 g/mol
Synonyms	Estra-1,3,5(10)-triene-2,3,16α,17β-tetrol; 2,3,16α,17β-Estriol; 2,3,16α,17β-Tetrahydroxyestra-1,3,5(10)-triene; 2-Hydroxy-16α,17β-estriol; 2-OH-Estriol
EINECS	Contact for details

Quality Control

Our 2-Hydroxyestriol is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container sealed to protect the light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.