Description

6Alpha-Hydroxyestradiol is a specific hydroxylated metabolite of the primary female sex hormone, estradiol. This compound is of significant interest in biochemical research and pharmaceutical development due to its role in estrogen metabolism and potential biological activity. It serves as a critical reference standard and intermediate for researchers and manufacturers in the life sciences sector, particularly those focused on endocrinology, steroid chemistry, and drug discovery.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of estradiol metabolites in method development, validation, and quality control (QC) laboratories.
• Biochemical Research: Employed as a tool compound in studies investigating estrogen metabolism pathways, enzyme kinetics (e.g., cytochrome P450), and receptor binding affinity.
• Metabolite Synthesis: Acts as a key synthetic intermediate or precursor for the preparation of other steroid derivatives and labeled compounds for tracer studies.
• Diagnostic Development: Utilized in the development and calibration of diagnostic assays and kits intended to measure hormonal profiles in clinical or research settings.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in endocrinology, cancer research, and toxicology.

Basic Information

Product Name	6Alpha-Hydroxyestradiol
CAS No.	1229-24-9
Molecular Formula	C18H24O3
Molecular Weight	288.38 g/mol
Synonyms	6α-Hydroxyestradiol; Estra-1,3,5(10)-triene-3,6α,17β-triol; 6α-Hydroxy-17β-estradiol; 3,6α,17β-Trihydroxyestra-1,3,5(10)-triene; 6α-OH-E2
EINECS	214-967-9

Quality Control

Every batch of our 6Alpha-Hydroxyestradiol is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure identity, purity, and consistency, which is critical for research and development applications. A detailed Certificate of Analysis (COA) including results from HPLC, NMR, and mass spectrometry is supplied with each shipment to guarantee it meets your precise specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.