Description

(3B)-3,17,21-Trihydroxy-Pregn-5-En-20-One CAS NO 1167-48-2 is a high-purity steroid intermediate, specifically a pregnane derivative with multiple hydroxyl groups. This compound is a critical building block in the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs) and fine chemicals. It is essential for pharmaceutical R&D and manufacturing, particularly for companies developing corticosteroids, anti-inflammatory agents, and other hormone-related therapies.

Application

• Pharmaceutical Intermediate: A key starting material or intermediate in the multi-step synthesis of corticosteroid drugs such as hydrocortisone, prednisolone, and their derivatives.
• Steroid Hormone Research: Used in biochemical and pharmacological research to study steroid metabolism, receptor binding, and the development of new therapeutic agents.
• Fine Chemical Synthesis: Serves as a chiral precursor for the production of specialized fine chemicals and complex organic molecules in advanced organic chemistry.
• Reference Standard: Employed as a high-purity analytical reference standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	(3B)-3,17,21-Trihydroxy-Pregn-5-En-20-One
CAS No.	1167-48-2
Molecular Formula	C21H32O4
Molecular Weight	348.48 g/mol
Synonyms	11-Deoxycortisol; 17,21-Dihydroxypregn-4-ene-3,20-dione; Reichstein's Substance S; 17α,21-Dihydroxy-4-pregnene-3,20-dione; Cortodoxone; 11-Desoxycortisol; 11-Deoxy-17-hydroxycorticosterone; Pregn-4-ene-17α,21-diol-3,20-dione
EINECS	214-579-8

Quality Control

Our (3B)-3,17,21-Trihydroxy-Pregn-5-En-20-One is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and specific impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.