Description

[5-(2,4-Dioxo-1H-Pyrimidin-5-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid CAS NO 1157-60-4 is a high-purity, nucleoside-derived phosphonate compound of significant interest in advanced pharmaceutical research and development. Its unique molecular structure, featuring a uracil base linked to a modified sugar-phosphate backbone, makes it a critical building block for novel therapeutic agents. This compound is essential for researchers and manufacturers in the fields of antiviral drug discovery, oncology, and nucleotide-based prodrug development, where precise chemical intermediates are required.

Application

• Antiviral Drug Synthesis: Serves as a key phosphonate intermediate in the development of nucleotide analogs targeting viruses such as hepatitis B (HBV), hepatitis C (HCV), and HIV.
• Oncological Therapeutics: Used in the research and production of prodrugs and targeted cancer therapies that interfere with DNA synthesis in rapidly dividing cells.
• Prodrug Development: Acts as a precursor molecule for designing masked phosphate prodrugs (e.g., ProTide technology) to enhance cellular uptake and bioavailability of active nucleotide metabolites.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and polymerase function.
• Radiopharmaceuticals: Potential use as a precursor for labeling with radioactive isotopes (e.g., Phosphorus-32) for diagnostic imaging or therapeutic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of client-specific novel chemical entities (NCEs).

Basic Information

Item	Details
Product Name	[5-(2,4-Dioxo-1H-Pyrimidin-5-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid
CAS No.	1157-60-4
Molecular Formula	C10H13N2O9P
Molecular Weight	336.19 g/mol
Synonyms	5-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,4-dihydroxyoxolan-2-yl methoxyphosphonic acid; Uracil nucleoside phosphonate; 5-(2,4-Dihydroxypyrimidin-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl methyl phosphonate; 5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl methylphosphonate; 1-[(2R,3S,4R)-3,4-Dihydroxy-5-(methoxyphosphono)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our [5-(2,4-Dioxo-1H-Pyrimidin-5-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) documenting identity, purity, and all critical parameters are provided to ensure compliance with your research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions or a dry inert atmosphere to prevent decomposition. For long-term storage, consider desiccants and temperature monitoring.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.