Description

12α-Acetyloxy-3α-Hydroxy-5β-Pregnan-20-One is a high-purity steroid derivative and a key intermediate in the synthesis of complex pharmaceutical compounds. Its defined stereochemistry and functional groups make it a valuable building block for research and development in medicinal chemistry. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of steroid-based APIs and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of steroidal active pharmaceutical ingredients (APIs) and other therapeutic agents.
• Medicinal Chemistry Research: Serves as a versatile scaffold for the design, synthesis, and structure-activity relationship (SAR) studies of novel steroid-based drug candidates.
• Reference Standard: Used as a certified reference material (CRM) or analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Employed in studies investigating steroid hormone metabolism, receptor interactions, and related biochemical pathways.
• Fine Chemical Synthesis: Acts as a specialized building block for the custom synthesis of complex organic molecules in contract research and manufacturing (CRAM) organizations.

Basic Information

Product Name	12α-Acetyloxy-3α-Hydroxy-5β-Pregnan-20-One
CAS No.	1102-96-1
Molecular Formula	C₂₃H₃₆O₄
Molecular Weight	376.53 g/mol
Synonyms	3α,12α-Dihydroxy-5β-pregnan-20-one 12-acetate; 12α-Acetoxy-3α-hydroxy-5β-pregnan-20-one; 3α-Hydroxy-12α-acetoxy-5β-pregnan-20-one; 5β-Pregnan-20-one, 12α-acetyloxy-3α-hydroxy-; 12α-Acetyloxy-3α-hydroxy-5β-pregnan-20-one; 12α-Acetoxy-3α-hydroxy-5β-pregnane-20-one
EINECS	Contact for details

Quality Control

Our 12α-Acetyloxy-3α-Hydroxy-5β-Pregnan-20-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets stringent specifications for research and pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.