Description

Thymidine 3'-Triphosphoric Acid CAS NO 1057-33-6 is a high-purity nucleotide derivative essential for biochemical research and pharmaceutical development. This compound serves as a critical building block and substrate in enzymatic reactions, particularly those involving DNA and RNA polymerases. It is primarily utilized by research institutions, diagnostic kit manufacturers, and biotechnology companies engaged in molecular biology, genomics, and drug discovery.

Application

• Enzymatic Synthesis Substrate: Used as a nucleotide triphosphate (NTP) substrate for DNA and RNA polymerases in in vitro transcription and replication assays.
• Molecular Biology Research: Essential for PCR (Polymerase Chain Reaction), cDNA synthesis, and site-directed mutagenesis experiments.
• Diagnostic Reagent Manufacturing: A key raw material in the production of diagnostic kits for genetic testing and viral detection.
• Biochemical Tool Development: Employed in the study of enzyme kinetics, nucleotide metabolism, and nucleic acid biochemistry.
• Pharmaceutical Intermediates: Acts as a precursor or intermediate in the synthesis of nucleotide-based antiviral or anticancer prodrugs.
• Labeling and Detection: Can be modified or labeled for use in non-radioactive detection methods and next-generation sequencing workflows.

Basic Information

Product Name	Thymidine 3'-Triphosphoric Acid
CAS No.	1057-33-6
Molecular Formula	C10H17N2O14P3
Molecular Weight	482.17 g/mol
Synonyms	Thymidine 3'-Triphosphate; 3'-TTP; 2'-Deoxythymidine 3'-triphosphate; dTTP (3'-isomer); Thymidine 3'-(tetrahydrogen triphosphate); 1-(2-Deoxy-β-D-erythro-pentofuranosyl)thymine 3'-triphosphate; TTP (3'-isomer); 3'-dTTP
EINECS	Contact for details

Quality Control

Our Thymidine 3'-Triphosphoric Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality commitment aligns with the standards expected for biochemical and pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	Contact for details
Endotoxin (LAL)	< 10 EU/mg (if required)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.