Description

[5-(6-Aminopurin-9-Yl)-4-Hydroxy-3-Phosphonooxy-Oxolan-2-Yl]Methoxyphosphonic Acid is a high-purity, chemically modified nucleotide analog of significant interest in advanced biochemical research and pharmaceutical development. This compound matters as a critical building block for synthesizing novel nucleotide derivatives and probes used to study enzymatic mechanisms and cellular signaling pathways. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on antiviral drug discovery, molecular biology, and the development of diagnostic assays.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel antiviral and anticancer nucleotide analog prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for kinases, polymerases, and phosphotransferases.
• Probe Development: Acts as a backbone for creating labeled nucleotides (e.g., fluorescent, radioactive) for diagnostic and research applications.
• Molecular Biology: Employed in the study of nucleic acid metabolism and the development of tools for genetic analysis.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Fine Chemical Synthesis: Used in custom synthesis services to produce specialized nucleotides for client-specific research programs.

Basic Information

Product Name	[5-(6-Aminopurin-9-Yl)-4-Hydroxy-3-Phosphonooxy-Oxolan-2-Yl]Methoxyphosphonic Acid
CAS No.	1053-73-2
Molecular Formula	C11H15N5O10P2
Molecular Weight	439.21 g/mol
Synonyms	9-[(2R,3S,4R,5R)-5-[(Methoxy(hydroxy)phosphoryl)methyl]-3,4-dihydroxyoxolan-2-yl]-6-aminopurine 3'-(dihydrogen phosphate); 2'-Deoxyadenosine-3',5'-bisphosphate; dADP; Deoxyadenosine diphosphate analog; Adenine nucleotide derivative; 2'-Deoxyadenosine 3',5'-bisphosphoric acid; 5'-O-[(Methoxyphosphinyl)methyl]-2'-deoxyadenosine 3'-(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our [5-(6-Aminopurin-9-Yl)-4-Hydroxy-3-Phosphonooxy-Oxolan-2-Yl]Methoxyphosphonic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.