Description

5-Iodouridine is a halogenated nucleoside analog of uridine, where a hydrogen atom at the 5-position is substituted with an iodine atom. This modification is crucial for its role as a key intermediate and building block in the synthesis of more complex nucleoside derivatives and oligonucleotides. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for applications in drug discovery, biochemical research, and diagnostic development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases and other nucleoside-metabolizing enzymes.
• Probe Development: Acts as a building block for creating labeled probes (e.g., radioiodinated or fluorescent) for molecular biology and diagnostic assays.
• Antiviral Studies: Investigated for its potential activity and mechanism in virology research due to its structural similarity to natural nucleosides.
• Oligonucleotide Synthesis: Employed in the solid-phase or solution-phase synthesis of modified oligonucleotides for therapeutic and research applications.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	5-Iodouridine
CAS No.	1024-99-3
Molecular Formula	C9H11IN2O6
Molecular Weight	370.10 g/mol
Synonyms	5-Iodo-1-β-D-ribofuranosyluracil; 5-Iodouridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-iodopyrimidine-2,4-dione; 5-IUrd; Iodouridine; 5-Iodo-1-β-D-ribofuranosyluracil; Uridine, 5-iodo-
EINECS	213-835-5

Quality Control

Our 5-Iodouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.