Description

2-Chloroadenosine is a chemically modified nucleoside analog of adenosine, where a chlorine atom replaces the hydroxyl group at the 2' position of the ribose sugar. This structural modification is critical for its role as a potent and selective agonist for adenosine receptors, particularly the A2A subtype, making it a valuable biochemical tool. It is primarily utilized by researchers and developers in the pharmaceutical and life sciences sectors for investigating cardiovascular, neurological, and inflammatory pathways. The compound is supplied with a focus on high purity and batch-to-batch consistency to ensure reliable experimental and developmental outcomes.

Application

• Biochemical Research: A key tool compound for studying adenosine receptor (A1, A2A, A2B, A3) pharmacology, signal transduction, and cellular responses.
• Pharmaceutical R&D: Serves as a reference standard and a critical intermediate in the discovery and development of novel therapeutics targeting adenosine pathways for conditions like Parkinson's disease, inflammation, and cardiac ischemia.
• Cell Biology Studies: Used to modulate cAMP levels in cell-based assays to investigate the role of adenosine receptors in immune regulation, neural function, and vasodilation.
• In Vitro Diagnostics: Employed in the development and calibration of assay kits designed to measure adenosine receptor activity or related enzymatic functions.
• Academic Research: Fundamental research in universities and institutes exploring purinergic signaling, neuroprotection, and cardioprotection mechanisms.

Basic Information

Product Name	2-Chloroadenosine
CAS No.	146-77-0
Molecular Formula	C10H12ClN5O4
Molecular Weight	301.69 g/mol
Synonyms	2-Chloro-9-β-D-ribofuranosyladenine; 2-Cl-Ado; 2-Chloroadenosine; 2-Chloro-9-β-D-ribofuranosyl-9H-purin-6-amine; Adenosine, 2-chloro-; 2-Chloro-adenosine; 2-CADO; 2-Chloro-9-(β-D-ribofuranosyl)adenine
EINECS	205-682-5

Quality Control

Our 2-Chloroadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Standard quality control includes HPLC for assay and purity determination, identification by IR and NMR spectroscopy, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥99.0% (Total area normalization)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.