Description

(+)-Griseofulvin CAS NO 126-07-8 is a specific enantiomer of the well-known antifungal antibiotic, griseofulvin, characterized by its unique spirocyclic structure. This compound is critically important for its potent inhibitory activity against dermatophytes, the fungi responsible for skin, hair, and nail infections. It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the production of oral antifungal medications, as well as by research institutions for microbiological and biochemical studies.

Application

• Pharmaceutical API: Primary use as the active ingredient in oral antifungal tablets and capsules for treating tinea infections (ringworm, athlete's foot, jock itch, fungal nail infections).
• Veterinary Medicine: Formulation into antifungal treatments for dermatophytosis in companion animals and livestock.
• Clinical Research: Used as a reference standard and investigational agent in studies of antifungal mechanisms of action and resistance.
• Microbiological Studies: Employed in laboratory settings for selective inhibition of fungal growth in culture media and susceptibility testing.
• Biochemical Research: Investigation of its interaction with microtubules and its effects on fungal cell division and nucleic acid synthesis.

Basic Information

Product Name	(+)-Griseofulvin
CAS No.	126-07-8
Molecular Formula	C17H17ClO6
Molecular Weight	352.77 g/mol
Synonyms	Griseofulvin; (+)-Griseofulvin; (2S,6'R)-7-Chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione; Amudane; Fulcin; Grifulvin; Grisactin; Grisovin; Lamoryl; Polygris; Giv
EINECS	204-767-4

Quality Control

Our (+)-Griseofulvin is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identity confirmation, assay, and impurity profiling. Certificates of Analysis (COA) detailing specifications against relevant pharmacopeial standards (such as USP/EP) are provided with each batch to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time conforms
Assay (HPLC)	98.0% - 102.0%
Specific Rotation	+352° to +367°
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.