Description

2,2,2,4'-Tetrafluoroacetophenone is a specialized fluorinated aromatic ketone, a key building block in advanced organic synthesis. Its unique structure, featuring a trifluoromethyl and a para-fluoro substituent, makes it a critical intermediate for creating molecules with enhanced stability, lipophilicity, and biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential candidates for central nervous system (CNS) drugs and anti-inflammatory agents.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides where the fluorine atoms improve metabolic stability and membrane permeability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, enhancing charge transport and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart chemical resistance, lower surface energy, and improve weatherability.
• Organic Synthesis Reagent: Employed in Friedel-Crafts acylation and other reactions to introduce the 2,2,2,4'-tetrafluoroacetophenone moiety into complex molecular architectures.
• Fluorine Chemistry Research: A valuable standard and reactant in academic and industrial R&D focused on exploring the effects of strategic fluorine substitution.

Basic Information

Product Name	2,2,2,4'-Tetrafluoroacetophenone
CAS No.	655-32-3
Molecular Formula	C8H4F4O
Molecular Weight	192.11 g/mol
Synonyms	2,2,2-Trifluoro-1-(4-fluorophenyl)ethanone; 4'-Fluoro-2,2,2-trifluoroacetophenone; 1-(4-Fluorophenyl)-2,2,2-trifluoroethanone; α,α,α,4'-Tetrafluoroacetophenone; p-Fluoro-α,α,α-trifluoroacetophenone; 4-Fluorophenyl trifluoromethyl ketone; TFAP (abbrev.)
EINECS	211-483-3

Quality Control

Every batch of 2,2,2,4'-Tetrafluoroacetophenone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets your specific research or production requirements. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC/HPLC is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.440 - 1.450
Density (20°C)	1.40 - 1.45 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.