Antihypertensives

Antihypertensives

Antihypertensive drugs lower elevated blood pressure and reduce the long-term risk of stroke, heart failure, coronary disease, and kidney damage. Major classes include diuretics, ACE inhibitors, ARBs, calcium channel blockers, β-blockers, and centrally acting agents. Their mechanisms involve reducing circulating volume, relaxing vascular smooth muscle, blocking neurohormonal activation, or decreasing cardiac output. Antihypertensives are tailored to patient comorbidities such as diabetes, chronic kidney disease, or heart failure. Long-term control greatly improves survival and prevents complications. Monitoring is required to avoid adverse effects such as electrolyte disturbances, renal dysfunction, bradycardia, or orthostatic hypotension. Antihypertensives remain fundamental in global cardiovascular disease prevention.

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