Alkylating Antineoplastic Agents

Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

n-Denitroso-N'-Nitroso Lomustine CAS NO 54749-91-6

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CAS No.:54749-91-6

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Content:99.90%

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Nitrocaphane CAS NO 54940-95-3

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CAS No.:54940-95-3

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Bofumustine CAS NO 55102-44-8

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CAS No.:55102-44-8

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Nimustine Hydrochloride CAS NO 55661-38-6

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CAS No.:55661-38-6

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N,n-Bis(2-Chloroethyl)-4-(Naphthalen-1-Yliminomethyl)Aniline CAS NO 56133-60-9

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CAS No.:56133-60-9

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Rfcnu CAS NO 56194-22-0

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CAS No.:56194-22-0

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4Α-[3-(2-Chloroethyl)-3-Nitrosoureido]Cyclohexane-1Α-Acetic Acid CAS NO 56208-24-3

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CAS No.:56208-24-3

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1-(2-Chloroethyl)-3-(4-Hydroxycyclohexyl)-1-Nitroso-Urea CAS NO 56239-24-8

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CAS No.:56239-24-8

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