Description

Mafosfamide Cyclohexylamine Salt is a chemically modified derivative of the active metabolite of the antineoplastic agent ifosfamide, designed to enhance stability and handling properties. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a prodrug in targeted cancer therapies. It serves as a critical intermediate and reference standard for researchers and manufacturers in the oncology and pharmaceutical sectors, supporting the development of novel chemotherapeutic agents and analytical method validation.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced chemotherapeutic prodrugs and related active pharmaceutical ingredients (APIs).
• Oncology Research: Used as a reference standard and active compound in preclinical studies to investigate mechanisms of action, efficacy, and toxicity profiles.
• Prodrug Development: Serves as a model compound for designing and testing new prodrug strategies aimed at improving drug targeting and reducing systemic side effects.
• Analytical Chemistry: Employed as a high-purity standard for quality control (QC) and assurance (QA) in HPLC, LC-MS, and other analytical methods within pharmaceutical manufacturing.
• Biochemical Studies: Utilized in studies exploring DNA alkylation and cross-linking mechanisms relevant to cancer cell apoptosis.

Basic Information

Product Name	Mafosfamide Cyclohexylamine Salt
CAS No.	88746-71-8
Molecular Formula	C10H18Cl2N3O4P • C6H13N
Molecular Weight	Contact for details
Synonyms	4-Hydroxy-Ifosfamide Cyclohexylamine Salt; Cyclohexylamine, 4-hydroxy-ifosfamide salt; NSC 345842 Salt; Z-7557 Salt; 2-[Bis(2-chloroethyl)amino]tetrahydro-4-hydroxy-2H-1,3,2-oxazaphosphorine 2-oxide cyclohexylamine salt; Mafosfamide (cyclohexylamine); Ifosfamide metabolite 4-OH derivative salt
EINECS	Contact for details

Quality Control

Our Mafosfamide Cyclohexylamine Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and determination of residual solvents and related substances to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	≤ 2.0% total
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.